CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 80 enrolled
Drug / intervention
Ultrasound-guided Femoral Nerve Block +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07478783
NCT07478783N/ACompleted

Addition Of Genicular Nerve Block To Femoral Nerve Block Improves Early Postoperative Analgesia After Total Knee Replacement: A Randomized Controlled Trial

Ankara City Hospital Bilkent·interventional·Posted Mar 18, 2026·Updated Mar 25, 2026

In Brief

A clinical study evaluating Ultrasound-guided Femoral Nerve Block and ltrasound-guided Genicular Nerve Block for Total Knee Anthroplasty. Completed, enrolled 80 participants across 2 sites.

Detailed Summary

Total knee arthroplasty (TKA) is a common orthopedic procedure in which effective postoperative pain management is important for early mobilization and rehabilitation. Various regional anesthesia techniques are used as part of multimodal analgesia protocols to improve postoperative pain control. Genicular nerve block has recently been introduced as a potential motor-sparing technique that may enhance postoperative analgesia when used alone or in combination with other regional blocks. The aim of this randomized controlled study is to evaluate whether the addition of ultrasound-guided genicular nerve block to femoral nerve block improves early postoperative analgesia in patients undergoing primary unilateral total knee arthroplasty under combined spinal-epidural anesthesia. A total of 80 patients aged 18-80 years scheduled for elective primary unilateral TKA will be included and randomly assigned to two groups using sealed envelopes. One group will receive femoral nerve block alone (Group F), while the other group will receive femoral nerve block combined with genicular nerve block (Group FG). Postoperative pain scores using the visual analog scale (VAS), epidural patient-controlled analgesia consumption during the first 24 hours, and the time to additional analgesic requirement will be recorded and compared between the groups.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesTurkey (Türkiye)
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedMar 18, 2026
Enrollment StartNov 1, 2021
Primary CompletionNov 1, 2021
Study CompletionFeb 28, 2022
TodayJul 2, 2026
Enrollment to primary: 0 daysPosted 3 months ago

Interventions

Ultrasound-guided Femoral Nerve Blockprocedure

Administration of 20 ml of 0.25% bupivacaine to the femoral nerve under ultrasound guidance. This procedure was performed on patients in both Group F and Group FG

ltrasound-guided Genicular Nerve Blockprocedure

Administration of 5 ml of 0.25% bupivacaine to each of the four genicular nerve branches (superomedial, superolateral, inferomedial, and inferolateral) under ultrasound guidance. This procedure was performed only on patients in Group FG