At a glance
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Frontostriatal Connectivity and Gene Expression in Exercise-induced Relief of Back Pain
In Brief
A clinical study evaluating Supervised physical exercise training for Chronic Low Back Pain (CLBP). Completed, enrolled 57 participants across 1 site.
Detailed Summary
This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating frontostriatal brain connectivity and immune-related gene expression. Fifty-seven adults with CLBP were randomized to exercise training or wait-list control. Participants underwent pre- and post-intervention MRI, questionnaires, and blood sampling. The study tested whether reductions in nucleus accumbens-medial prefrontal cortex connectivity and changes in inflammatory gene expression mediated exercise-induced pain relief.
Study Details
Timeline
Interventions
60-minute sessions 3 times weekly Aerobic + resistance training Individually calibrated intensity (VO2max, 1RM) Total duration: 14 weeks