At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effects of Perioperative Hyperoxia Versus Normoxia on Pulmonary, Endothelial, and Inflammatory Biomarkers in Elective Laparoscopic Lower Abdominal Surgery
In Brief
A clinical study evaluating Perioperative Oxygen Strategy - Normoxia and Perioperative Oxygen Strategy-Hyperoxia for Hyperoxia and 3 related conditions. Completed, enrolled 76 participants across 1 site.
Detailed Summary
This single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia. Participants were assigned to receive either normoxia (FiO2 0.35) or hyperoxia (FiO2 0.80) after intubation and throughout the intraoperative period. The study assessed perioperative changes in circulating biomarkers related to pulmonary epithelial stress, endothelial glycocalyx injury, oxidative stress, and inflammation, together with blood gas and hemodynamic parameters. The study was completed before registration and is being registered retrospectively.
Study Details
Timeline
Interventions
Normoxia arm: FiO2 0.35 Intervention started immediately after intubation and maintained intraoperatively
Hyperoxia arm: FiO2 0.80 Intervention started immediately after intubation and maintained intraoperatively