CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 50 enrolled
Drug / intervention
Capsaicin Topical Cream +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07598994
NCT07598994N/ACompleted

Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain: A Randomized, Prospective, Single-Blind Clinical Trial

Istanbul University·interventional·Posted May 20, 2026·Updated May 20, 2026

In Brief

A clinical study evaluating Capsaicin Topical Cream and Diclofenac 1% Topical for Temporomandibular Disorders (TMD) and Temporomandibular Pain. Completed, enrolled 50 participants across 1 site.

Detailed Summary

The goal of this clinical trial is to compare the effectiveness and safety of topical capsaicin cream and topical diclofenac gel in women with chronic temporomandibular joint-related pain. The main questions it aims to answer are: * Does topical capsaicin reduce pain intensity more effectively than topical diclofenac? * Do the treatments improve jaw function, pressure pain threshold, and neuropathic pain symptoms? Researchers will compare topical capsaicin cream with topical diclofenac gel to evaluate differences in pain relief and functional improvement. Participants will: * Apply the assigned topical medication four times daily for 7 days * Attend clinical examinations and pain assessments at baseline, Day 8, and Month 1 * Complete pain-related questionnaires and functional jaw measurements during follow-up visits

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesTurkey (Türkiye)

Timeline

N/ACompletedFinished
2026
First PostedMay 20, 2026
Enrollment StartApr 1, 2025
Primary CompletionApr 5, 2026
TodayJul 2, 2026
Enrollment to primary: 1.0 yearsPosted 1 month ago

Interventions

Capsaicin Topical Creamdrug

Topical capsaicin cream applied four times daily over the temporomandibular joint region for 7 days.

Diclofenac 1% Topicaldrug

Topical diclofenac diethylammonium gel applied four times daily over the temporomandibular joint region for 7 days.