At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
DEX-HIP Trial: Preoperative IV Dexamethasone 4 mg vs Placebo to Reduce Postoperative Delirium Burden in Adults ≥70 Undergoing Hip Fracture Surgery : a Randomized Double-blind Trial.
In Brief
A clinical study evaluating Dexamethasone and Placebo for Delirium - Postoperative and 2 related conditions. Completed, enrolled 120 participants across 1 site.
Signals
Detailed Summary
This single-center, prospective, randomized, double-blind, placebo-controlled trial was conducted at the Department of Orthopaedic Surgery, JPMC, Karachi. Patients aged ≥60 years with hip fractures were randomized 1:1 to receive either intravenous dexamethasone or a placebo preoperatively. The primary outcome was the incidence of POD within the first five postoperative days or until discharge, assessed via the Confusion Assessment Method. Delirium severity was quantified using the validated Memorial Delirium Assessment Scale.
Study Details
Timeline
Arms & Interventions
Participants received a single preoperative intravenous dose of dexamethasone 4 mg before operative management of hip fracture.
Participants received an equivalent volume of normal saline placebo preoperatively.
Interventions
A single 4 mg intravenous dose administered preoperatively.
Participants received an equivalent volume of normal saline placebo preoperatively.